Previous research had already proven that low-calorie diets and inhibiting insulin signalling - blocking the signal between insulin and cells - could delay ageing and extend lifespan in many animals.
The "machine" - as Beyer calls it - responsible for making the transcription copy of the gene sequences is called Pol II (RNA polymerase II).Īnd what his team discovered was that the process of transcription gets faster as we age, and this accelerated transcription causes Pol II to make more mistakes, leading to essentially “bad” copies that can lead to numerous diseases. And because each cell fulfils a different function, a different set of genes are activated (transcribed) in each cell type.
GO TRANSCRIBE SKIN
There are many different types of cells in the human body: nerve cells, muscle cells, blood cells, skin cells, and so on. "You need to create the right amount of transcripts for each gene and have an exact copy of the gene sequence, but also, you need to activate the exact genes that the cell needs to function as it should," Beyer said.
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